Nanofiber Myelination Assay

There are currently two myelination assays under development to evaluate myelination in cultured conditions. The first is a three-dimentional nanofiber culture system. In this assay, oligodendrocytes produce PLP+/MBP+ sheaths wrapping around nanofibers. The length and thickness of the wrapping correlate with the extent of myelination. This assay can be used to evaluate therapeutics that promote formation of compact myelin, or to screen for molecules with the potential to promote myelination from compound libraries.