MS Animal Models

Renovo’s Preclinical Model Systems Accelerate Drug Development for MS and other Neural Diseases

MS is a chronic inflammatory demyelinating disease of the central nervous system (CNS) with no definitive cause or cure.  The disease stems from a complex interaction between the immune system and CNS resulting in progressive destruction of oligodendrocytes and axonal demyelination. Renovo offers a portfolio of animal models that mimic the primary clinical and pathological features in MS thus providing a diverse tool kit for efficacy studies of different therapeutic and restorative approaches.

  • Remyelination
    Renovo’s modified cuprizone model shows consistent levels of axonal demyelination providing an excellent platform for qualitative and quantitative readouts of remyelination. To learn more about what sets Renovo’s remyelination model apart from other cuprizone models, click here.
  • Neuroprotection
    Renovo’s cuprizone model recapitulates axonal pathological changes of MS lesions to evaluate neuroprotective therapeutics.
  • Immunomodulation
    Renovo’s MOG-EAE model induces disease as a result of T-cell response resembling a primary progressive phenotype of MS.