MOG-EAE Mouse Model

 
Renovo offers a MOG35-55 (myelin oligodendrocyte glycoprotein) peptide-induced chronic EAE (experimental autoimmune encephalomyelitis) model in C57BL/6 mice, where the disease is induced  as a result of encephalitogenic T-cell response resembling a primary progressive phenotype of MS. Renovo’s EAE resembles several pathological features and clinical symptoms of MS, including inflammation, neurodegeneration, paralysis, and demyelination of the spinal cord.
 

 
 

EAE mouse spinal cord stained with Luxol Fast blue for lesion quantification

 
 
Experimental Endpoints:

  • Clinical paralysis scoring.
  • In Vivo MRI imaging to evaluate white matter changes, axonal damage, and atrophy in spinal cord
  • Histopathology – quantification of lesion load, demyelination, neuronal cell loss, etc
  • Histopathology – quantification of microglia, astrocytes, infiltration of immune cells, etc
  • Evaluation of myelin and axonal parameters by 3D-EM