Preclinical MRI

 
Magnetic resonance imaging (MRI) is a cornerstone of clinical studies and research of several neurodegenerative disorders including multiple sclerosis, Alzheimer’s, traumatic brain injury, etc. It is one of the primary tools to evaluate the effectiveness of potential treatments due to its ability to provide immediate, predictive data while being non-invasive. Rodent MRI studies on preclinical animal models of neurodegenerative diseases can increase the efficiency of these studies; thereby helping improve translation from preclinical testing to clinical testing of potential therapeutics. MRI’s high resolution, image analysis tools, and statistical capabilities provide a robust platform to better understand biological processes and translational readouts to develop new treatment approaches for several CNS diseases. Renovo Neural now offers MRI-based imaging applications-acquisition, post-processing, and data analysis developed for small animal preclinical models of neurodegenerative diseases. This includes longitudinal studies with multiple imaging endpoints that can be combined with other traditional readouts including behavioral, electrophysiology, histology, and electron microscopy – leading to a more comprehensive evaluation of a potential therapeutic.
 
Some of our MRI preclinical readouts include:

  • Anatomical MRI – T1/T2 imaging for structural/volumetric & atrophy measurements
  • MT weighted imaging (MTR) – myelin sensitivity
  • Diffusion tensor imaging (DTI) – tissue integrity in white matter
  • Manganese enhanced-MRI (MEMRI) – neuronal function
  • Contrast based imaging – tumor/blood vessel volumetric
  • Functional MRI (fMRI) – brain activity
  • Pharmacological MRI (phMRI) – brain function

 
 

Structural MRI

 
 

Diffusion Tensor Imaging (DTI) MRI

 
 

TBI and Stroke

 
 

Proof of Concept: The corpus callosum (CC) shows almost a 50% difference in myelin loss sensitive MTw MRI metric in chronically demyelinated mice compared to controls. This is corroborated postmortem by IHC and histology; there is a significant reduction in density of myelinated axons in the CC of the chronically demyelinated mice. The hippocampus is also significantly affected in the Cuprizone-Rapamycin mouse model, and is consistent with memory and learning deficits seen in these animals.


 
Please see links below for MRI publications:

MRI detects the effects of demyelination and remyelination on hippocampal structure and function  (ISMRM, 2016)